Modeling Kinetics of Subcellular Disposition of Chemicals

Modeling Kinetics of Subcellular Disposition of Chemicals

Introduction to radiotracer disposition kinetics: analysis by mathematical modeling.

The most prevalent use of a radioactive tracer is to assess specific organ function for diagnostic purpose. This analysis is performed by obtaining a time-activity curve of the tracer and then developing an appropriate mathematical model for disposition kinetics of the tracer. This article provides an introductory guide to several aspects of this method, which has been successfully applied in v...

Effect of Carbontetrachloride-Induced Hepatopathy on the Disposition Kinetics of Closantel in Goats

Clinically healthy adult black Bengal female goats were used to investigate the pharmacokinetics of closantel following intravenous administration (10 mg/kg) both in healthy and in liver damaged goats. Induction of liver damage was done by subcutaneous injection of carbontetrachloride at 0.75 mL/kg on three occasion at 48 h interval. After administration of drug, blood samples were collected in...

Disposition kinetics of orbifloxacin in tissues of crucian carp (Carassius auratus) following a single intramuscular administration

Background: Orbifloxacin is being widely used in China to treat fish infections in an extra-label manner, which may cause its potential residues in edible tissues. Aims: The purpose of this study was to determine the disposition kinetics of orbifloxacin in crucian carp (Carassius auratus) following intramuscular administration for its further safe appl...

Protective Effect of Ocimum sanctum on Disposition Kinetics of Sulphadimidine in Lead-Treated Cockerel

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